Recurrence of sarcoidosis following bilateral allogeneic lung transplantation.

نویسندگان

  • F J Martinez
  • J B Orens
  • M Deeb
  • L A Brunsting
  • A Flint
  • J P Lynch
چکیده

We report the first case of recurrent sarcoidosis manifested by clinical symptoms, radiographic abnormalities, and pathologic changes in a patient following sequential double allogeneic lung transplantation. A 40-year-old male patient underwent bilateral allogeneic lung transplantation for end-stage pulmonary sarcoidosis. Thirteen months posttransplantation, he developed fatigue, shortness of breath, and bilateral upper lobe pulmonary infiltrates. Transbronchial biopsy specimens revealed noncaseating granulomata. The patient's symptoms and radiographic abnormalities resolved with an increased dose of oral prednisone.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Pulmonary sarcoidosis following stem cell transplantation: is it more than a chance occurrence?

Noninfectious pulmonary complications are one of the major side effects of hematopoetic stem cell transplant (HSCT); however, the development of pulmonary sarcoidosis post-HSCT is uncommon, with only three cases previously reported. In each of those cases, sarcoidosis was also diagnosed in the stem cell donor. We now report four cases of de novo pulmonary sarcoidosis occurring post-HSCT (3 auto...

متن کامل

Medium term results of lung transplantation for end stage pulmonary sarcoidosis.

BACKGROUND Lung transplantation is an accepted therapeutic option for patients with end stage pulmonary sarcoidosis. However, the medium term outcome of transplantation in this patient group is unknown. METHODS This study was performed to evaluate our experience with lung transplantation for end stage pulmonary sarcoidosis. Between July 1988 and July 1997 12 patients (nine men) underwent lung...

متن کامل

Coincidence of Sarcoidosis With Ankylosing Spondylitis in a 48-Year-Old Woman; A Therapeutic Challenge

Introduction: A case of pulmonary sarcoidosis is reported because of difficulties in diagnosis and treatment, including the co-existence of ankylosing spondylitis (AS) and severe corticosteroid dependence. Case Presentation: A 48-year-old nonsmoking woman referred to the hospital because of chronic nonproductive cough and dyspnea with a 10-year history of...

متن کامل

Tumour necrosis factor-α gene expression by alveolar macrophages in human lung allograft recipient with recurrence of sarcoidosis

Tumour necrosis factor-α gene expression by alveolar macrophages in human lung allograft recipient with recurrence of sarcoidosis. S. Martel, P.C. Carré, G. Carrera, B. Pipy, P.J. Léophonte and the Toulouse Lung Transplantation Group. ©ERS Journals Ltd 1996. ABSTRACT: Recurrence of sarcoidosis in lung allografts is an interesting model to study the pathogenesis of this disease. We report a case...

متن کامل

Recurrent sarcoidosis after lung transplantation.

A 43-year-old man had undergone bilateral lung transplantation 2 years previously for sarcoidosis stage 4 fibrocystic disease. The patient feels well, without significant symptoms, sputa, cough or fever. A control spirometry however showed a highly obstructive, mildly restrictive pulmonary function, with a very low diffusion capacity. Laboratory results revealed a CRP of 6.4 mg/l (nl <= 5 mg/l)...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Chest

دوره 106 5  شماره 

صفحات  -

تاریخ انتشار 1994